However, the effect of statins on chronic kidney disease (CKD) progression remains
Mortality and morbidity rates after AMI are increased even with mild renal impairment and continue to increase rapidly when the estimated glomerular filtration
48 (IQR
Because many patients who have developed rhabdomyolysis during simvastatin therapy have had complicated medical histories, including renal
DOSE IN RENAL IMPAIRMENT GFR (mL/MIN) 20 to 50 : Dose as in normal renal function; 10 to 20 : Dose as in normal renal function; 10 : 10 to 20 : mg daily
There are 6 disease interactions with simvastatin
Renal impairment, hypothyroidism, personal or familial history of hereditary muscular disorders, previous history of unexplained muscle pain (whether associated or not with previous lipid-regulating drugs), a history of From their clinical data, we determined the effects of statins on renal parameters after a 53-week period
Restricted Use of Simvastatin 80 mg/day: Simvastatin 80 mg dose should only be used in patients who have taken this dose chronically (e
Other drugs in class December 22, 2021: Emergency use authorization issued for treatment of mild-to-moderate coronavirus disease 2019 (COVID-19) in adults who are at high risk for progression to severe COVID-19, including hospitalization or death
19 , 20 , 21 Therefore, the effect of Statins are the most frequently used lipid-lowering drugs in all cardiovascular disease
Geriatric That label states that, because renal impairment is a risk factor for statin-associated myopathy, doses of simvastatin exceeding 20 mg should be used with caution and close monitoring when administered concomitantly with ZETIA in patients with moderate to severe renal impairment
35, 36 These different consequences between the 2 statins could increase in patients with renal impairment, because their plasma coenzyme Q10 concentrations
In patients with severe renal impairment (CLcr 15 – 29 mL/min), the recommended starting dosage is simvastatin 5 mg once daily [see DOSAGE AND ADMINISTRATION (2
The polymorphis
Patients with impaired renal function may be at increased risk of developing rhabdomyolysis
6) ]
In patients with severe renal insufficiency (creatinine clearance < 30 mL/minute), dosages above 10 mg/day should be carefully considered and, if Generic Name: simvastatin
73m²): No dosage adjustment necessary SLCO1B1 polymorphism is thought to have a lesser effect on the more hydrophilic statins (eg, rosuvastatin, fluvastatin) compared with those that are more lipophilic (eg, atorvastatin, pravastatin, simvastatin) In severe renal impairment doses above 10mg should be used with caution (doses up to 40mg daily have been used)