Simvastatin is available in strengths of 5 mg, 10 mg, 20 mg, 40 mg, and 80 mg
Special populations Simvastatin: Dosage, Mechanism/Onset of Action, Half-Life - Medicine
Simvastatin is a prodrug in which the 6-membered lactone ring of simvastatin is hydrolyzed to generate the beta,delta-dihydroxy acid, an active metabolite structurally
Atorvastatin, cerivastatin (withdrawn from clinical use in 2001), fluvastatin, pitavastatin
12
57 for simvastatin and 16
liver problems - nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes)
This causes decreases in the V area (volume at the terminal phase of elimination), clearance, and an increase in half-life (12
Other HMG-CoA reductase inhibitors are either natural, mevinic acid derived (lovastatin, simvastatin, pravastatin) or synthetic, heptenoic acid derived (atorvastatin, fluvastatin)
Adult dosage (ages 18 years and older) Typical starting dosage: Simvastatin is often started at 10–20 mg per day
The C max and AUC of total simvastatin acid (naive simvastatin acid plus that derived by hydrolysis of the lactone) were increased 17-fold and 19-fold respectively, and the half-life was increased by 25%
After being processed, simvastatin turns into its active form, simvastatin acid, which has a half-life of around one to two hours
A drug's half life is an estimate of time it takes the amount of drug in the body to reduce by half
Protein Binding >95%
Clearance
Simvastatin acid and its metabolites are inhibitors of HMG-CoA reductase, the rate-limiting enzyme that converts HMG-CoA to mevalonate, a precursor of cholesterol
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Lovastatin, pravastatin and simvastatin are derived from fungal metabolites and have elimination half-lives of 1-3 h
After oral intake, this drug reaches peak blood plasma concentrations after approximately 3
However, concomitant verapamil increased the simvastatin area under the concentration:time curve (AUC) approximately fourfold, the maximum serum concentration (C(max)) fivefold, and the active metabolite simvastatin acid AUC and C(max) approximately four- and threefold, respectively (all comparisons p <0
Avoid use with pravastatin doses >40 mg
Statins are the most used therapeutic group in the treatment of hypercholesterolemia and reduce the risk of cardiovascular events and mortality
bilirubin and 17-β-glucuronosyl estradiol) for subsequent The pharmacokinetic parameters for simvastatin acid and simvastatin, There were no meaningful differences in T max or apparent T 1/2 between the two treatments for either simvastatin acid or simvastatin
If used together, avoid doses of